Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
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- Jin Meihua
- College of Pharmacy, Yeungnam University
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- Yang Ju Hye
- College of Pharmacy, Yeungnam University
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- Lee Eunkyung
- Daegu Gyeongbuk Institute for Oriental Medicine Industry
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- Lu Yue
- College of Pharmacy, Yeungnam University
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- Kwon Soonyoul
- Department of Food Science and Nutrition, Andong National University
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- Son Kun Ho
- Department of Food Science and Nutrition, Andong National University
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- Son Jong Keun
- College of Pharmacy, Yeungnam University
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- Chang Hyeun Wook
- College of Pharmacy, Yeungnam University
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説明
Previously, we reported that an ethanol extract of Ailanthus altissima has antiinflammatory activity in an ovalbumin (OVA)-sensitized murine asthmatic model. To determine the biological compounds from this plant, luteolin-7-O-glucoside (L7G) was isolated and its antiasthmatic activity was evaluated in an in vivo murine asthmatic model. L7G (10 to 100 mg/kg, per os (p.o.)) reduced the amount of eosinophil infiltration in bronchoalveolar lavage (BAL) fluid in a dose-dependent manner. In comparison, dexamethasone (5 mg/kg, p.o.), which was used as a positive control, also strongly inhibited the number of infiltrating eosinophils. L7G inhibited both the prostaglandin E2 (PGE2) and serum immunoglobulin E level in BAL fluid in a dose-dependent manner. In addition, L7G inhibited the transcript profiles of interleukin (IL)-4, IL-5, and IL-13 mRNA expression levels in the murine asthma model, as determined using reverse transcription-polymerase chain reaction (RT-PCR). These results suggest that the antiasthmatic activity of L7G in OVA-induced lung inflammation may occur in part via the downregulation of T helper 2 cytokine transcripts as well as the inhibition of PGE2 production.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 32 (9), 1500-1503, 2009
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601941504
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- NII論文ID
- 130000117273
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10332061
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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