In vitro and in vivo anticancer effects of American ginseng berry: exploring representive compounds

DOI Web Site Web Site 被引用文献2件 参考文献29件
  • Xie Jing-Tian
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Wang Chong-Zhi
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Zhang Bin
    Ben May Department for Cancer Research, University of Chicago
  • Mehendale Sangeeta Ram
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Li Xiao-Li
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Sun Shi
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Han Aung Htun
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago
  • Du Wei
    Department of Surgery, University of Chicago
  • He Tong-Chuan
    Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago
  • Yuan Chun-Su
    Tang Center for Herbal Medicine Research, University of Chicago Department of Anesthesia and Critical Care, University of Chicago Cancer Therapy and Research Center, University of Texas

書誌事項

タイトル別名
  • In Vitro and in Vivo Anticancer Effects of American Ginseng Berry: Exploring Representative Compounds

この論文をさがす

説明

Panax ginseng roots, including the steamed roots, have been demonstrated to possess anticancer properties. However, there have been limited published studies on the cancer preventive effects of American ginseng. In this study, the in vitro and in vivo anti-colorectal cancer effects of American ginseng berry extracts, and their representative bioactive compounds were evaluated. The ginsenoside content in unsteamed American ginseng berry extract (AGE) and steamed berry extract (S-AGE) were determined by HPLC. In comparison to AGE, S-AGE showed significantly stronger antiproliferative effects on HCT-116, SW-480 and HT-29 human colorectal cancer cells. Antiproliferative effects of representative constituents in AGE and S-AGE, ginsenosides Rb3 and Rg3, were also evaluated, showing that Rg3 had a positive effect. Using flow cytometric analyses, we found that S-AGE arrests cancer cells in G1-phase and significantly induces cell apoptosis. Using xenograft mice, we conducted an in vivo antitumor study using S-AGE after HCT-116 cell inoculation. We observed that 50 mg/kg of S-AGE showed significant antitumor effects. Our results suggested that S-AGE inhibited the colorectal cancer growth both in vitro and in vivo, and this inhibition might be achieved through cell cycle arrest and induced apoptosis in the cells.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (29)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ