A Combination of Soft-Shell Turtle Powder and Essential Oil of a Unicellular Chorophyte Prevents Bone Loss and Decreased Bone Strength in Ovariectomized Rats
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- Yin Jun
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University Shenyang Pharmaceutical University
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- Tezuka Yasuhiro
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Subehan
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Shi Liying
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Ueda Jun-ya
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Matsushige Katsumichi
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Kadota Shigetoshi
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
書誌事項
- タイトル別名
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- Combination of Soft Shell Turtle Powder and Essential Oil of a Unicellular Chorophyte Prevents Bone Loss and Decreased Bone Strength in Ovariectomized Rats
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説明
The effects of soft-shell turtle (Trionyx sinensis) powder (SST) on the proximal tibiae of ovariectomized (OVX) rats were investigated using peripheral quantitative computed tomography (pQCT) and examination of serum biochemical markers. Considering the relationship between the antioxidative property and antiosteoporotic activity, the synergistic effects of a mixture of SST and essential oil of the microalgae Haematococcus pluvialis (OHP) with strong antioxidant activity were also examined. Oral administration of SST (100, 200 mg/kg) or a mixture of SST (100, 200 mg/kg) and OHP (13, 26 mg/kg) three times weekly prevented the decrease in bone mineral content (BMC) in total bone, BMC and bone mineral density (BMD) in cortical bone, and bone strength indices induced by ovariectomy in a dose-dependent manner without uterine side effects. However, OHP alone showed no significant effects.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (2), 275-279, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602250624
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- NII論文ID
- 10016659951
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7233554
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- PubMed
- 15684483
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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