Contribution of Translin to Hematopoietic Regeneration after Sublethal Ionizing Irradiation
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- Fukuda Yuko
- Department of Immunology, National Institute of Infectious Diseases
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- Ishida Reiko
- Department of Immunology, National Institute of Infectious Diseases
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- Aoki Katsunori
- Department of Hematology, (Internal Medicine), The University of Tokyo
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- Nakahara Kazuhiko
- National Institution for Academic Degrees and University Evaluation
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- Takashi Tohru
- New Product Research Laboratories III, Tokyo R&D Center, Daiichi Pharmaceutical Co., Ltd.
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- Mochida Keiji
- Bioresource Center, RIKEN
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- Suzuki Osamu
- Department of Veterinary Science, National Institute of Infectious Diseases
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- Matsuda Junichiro
- Department of Veterinary Science, National Institute of Infectious Diseases
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- Kasai Masataka
- Department of Immunology, National Institute of Infectious Diseases
Bibliographic Information
- Other Title
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- Highlighted paper selected by editor-in-chief: Contribution of translin to hematopoietic regeneration after sublethal ionizing irradiation
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Abstract
The integrity of the genome is threatened by DNA damaging events such as radiation, viral infection and chemicals. Ionizing irradiation is known to cause genotoxic damage through the generation of reactive oxygen species (ROS) and nitrogen species (RNS) and we have found that a signaling pathway for the nuclear translocation of Translin is initiated in association and efficiently blocked by a specific inhibitor of nitric oxide synthase (NOS). This suggests the involvement of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) in the nuclear translocation of Translin. To address the functional significance of Translin in the hematopoietic generation system after ionizing irradiation, we generated Translin-deficient (Translin−/−) mice and examined hematopoietic colony formation after sublethal ionizing irradiation. We thereby confirmed a severe delay of colony formation in the spleens of Translin−/− as compared with Translin+/+ mice. Taken together, the results suggest that Translin contributes to hematopoietic regeneration by acting as a sensor protein for radiation-induced damage.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 31 (2), 207-211, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679602423552
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- NII Article ID
- 110006570556
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 9351206
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed