β-citryl-L-glutamate is an endogenous iron chelator that occurs naturally in the developing brain
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- Hamada-Kanazawa Michiko
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- Kouda Makiko
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- Odani Akira
- Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University
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- Matsuyama Kaori
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- Kanazawa Kiyoka
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- Hasegawa Tatsuya
- Department of Environmental Biochemistry, Yamanashi Institute of Environmental Sciences
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- Narahara Masanori
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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- Miyake Masaharu
- Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
書誌事項
- タイトル別名
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- .BETA.-Citryl-L-glutamate Is an Endogenous Iron Chelator That Occurs Naturally in the Developing Brain
- v citryl L glutamate is an endogenous iron chelator that occurs naturally in the developing brain
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The compound β-citryl-L-glutamate (β-CG) was initially isolated from developing brains, while it has also been found in high concentrations in testes and eyes. However, its functional roles are unclear. To evaluate its coordination with metal ions, we performed pH titration experiments. The stability constant, logβpqr for Mp(β-CG)qHr was calculated from pH titration data, which showed that β-CG forms relatively strong complexes with Fe(III), Cu(II), Fe(II) and Zn(II). β-CG was also found able to solubilize Fe more effectively from Fe(OH)2 than from Fe(OH)3. Therefore, we examined the effects of β-CG on Fe-dependent reactive oxygen species (ROS)-generating systems, as well as the potential ROS-scavenging activities of β-CG and metal ion-(β-CG) complexes. β-CG inhibited the Fe-dependent degradation of deoxyribose and Fe-dependent damage to DNA or plasmid DNA in a dose-dependent manner, whereas it had no effect on Cu-mediated DNA damage. In addition, thermodynamic data showed that β-CG in a physiological pH solution is an Fe(II) chelator rather than an Fe(III) chelator. Taken together, these findings suggest that β-CG is an endogenous low molecular weight Fe chelator.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (5), 729-737, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602431360
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- NII論文ID
- 130000248029
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10661991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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