Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo
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- Yoshida Tokuyuki
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Yoshioka Yasuo
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University
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- Fujimura Maho
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Kayamuro Hiroyuki
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Yamashita Kohei
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Higashisaka Kazuma
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Nakanishi Ryosuke
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Morishita Yuki
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Nabeshi Hiromi
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Yamashita Takuya
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Muroi Masashi
- Research Institute of Pharmaceutical Sciences, Musashino University
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- Tanamoto Kenichi
- Research Institute of Pharmaceutical Sciences, Musashino University
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- Nagano Kazuya
- Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Abe Yasuhiro
- Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Kamada Haruhiko
- Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University
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- Kawai Yuichi
- Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
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- Mayumi Tadanori
- Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
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- Itoh Norio
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University
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- Yoshikawa Tomoaki
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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- Tsunoda Shinichi
- Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University
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- Tsutsumi Yasuo
- Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University
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Abstract
Urban air pollution, especially in developing countries, is a crucial environmental problem. Urban aerosols may contain various kinds of substances and induce harmful effects such as allergic diseases. Therefore, it is critical to clarify the biological effects of urban aerosols on human health. In this study, we evaluated the induction of airway inflammation in vitro and in vivo due to exposure of urban aerosols. We investigated cytokine production and nuclear factor-κB (NF-κB) activation after stimulation of macrophage cells by exposure of urban aerosols. Urban aerosols were found to induce the production of interleukin (IL)-8, tumor necrosis factor-α and IL-1β on macrophage cells. In addition, we showed that NF-κB pathway regulated the urban aerosols-induced inflammatory cytokine response. Moreover, the intranasal administration of urban aerosols resulted in increases in the total cell number in bronchoalveolar lavage and infiltration of eosinophils in lung tissue. These results indicate that urban aerosols induce respiratory inflammation and onset of inflammatory disease due to an activation of the immune system.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 33 (5), 780-783, 2010
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679602455552
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- NII Article ID
- 130000248036
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 10662094
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed