Involvement of Na+/Ca2+ exchanger in pentylenetetrazole induced convulsion by use of Na+/Ca2+ exchanger knockout mice

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  • Saito Ryo
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Kaneko Erina
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Tanaka Yusuke
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Honda Kenji
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Matsuda Toshio
    Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Baba Akemichi
    Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Science, Osaka Prefecture University
  • Komuro Issei
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
  • Kita Satomi
    Department of Pharmacology, School of Medicine, Fukuoka University
  • Iwamoto Takahiro
    Department of Pharmacology, School of Medicine, Fukuoka University
  • Takano Yukio
    Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

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  • Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice

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Involvement of Na+/Ca2+ exchanger (NCX) in pentylenetetrazol (PTZ)-induced convulsion by use of NCX knockout mice and the selective ligand SEA0400 to NCX was examined. In the SEA0400-administered group, the latency to clonic convulsion was extended into 210 s, although the latency to clonic convulsion was observed until 100 s in control group. SEA0400 had little effect on bicuculline-induced clonic seizure nicotine-induced wild running and 4-aminopyridine-induced tonic flexion, respectively. Tonic flexion convulsion was occurred three fifth in the wild type mice group by administration of PTZ, but tonic flexion was not observed in NCX1 knockout mice groups. These results suggest that NCX is involved in inhibitory action in PTZ-induced convulsion.

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