Preservative Effect of Electrolyzed Reduced Water on Pancreatic .BETA.-Cell Mass in Diabetic db/db Mice

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  • Kim Mi-Ja
    Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University Imagine Obesity Institute, 117 Purynsol Mun Wa Gyun, Kyung Hee University
  • Jung Kyung Hee
    Department of Pharmacology, College of Medicine, Kyung Hee University
  • Uhm Yoon Kyung
    Department of Pharmacology, College of Medicine, Kyung Hee University
  • Leem Kang-Hyun
    College of Korean Medicine, Semyung University
  • Kim Hye Kyung
    Department of Food and Biotechnology, Hanseo University

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  • Preservative Effect of Electrolyzed Reduced Water on Pancreatic β-Cell Mass in Diabetic db/db Mice
  • Preservative Effect of Electrolyzed Reduced Water on Pancreatic ベータ Cell Mass in Diabetic db db Mice

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Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic β-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved β-cell mass in db/db mice. The present data suggest that ERW may protects β-cell damage and would be useful for antidiabetic agent.

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