Preservative Effect of Electrolyzed Reduced Water on Pancreatic .BETA.-Cell Mass in Diabetic db/db Mice
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- Kim Mi-Ja
- Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University Imagine Obesity Institute, 117 Purynsol Mun Wa Gyun, Kyung Hee University
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- Jung Kyung Hee
- Department of Pharmacology, College of Medicine, Kyung Hee University
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- Uhm Yoon Kyung
- Department of Pharmacology, College of Medicine, Kyung Hee University
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- Leem Kang-Hyun
- College of Korean Medicine, Semyung University
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- Kim Hye Kyung
- Department of Food and Biotechnology, Hanseo University
Bibliographic Information
- Other Title
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- Preservative Effect of Electrolyzed Reduced Water on Pancreatic β-Cell Mass in Diabetic db/db Mice
- Preservative Effect of Electrolyzed Reduced Water on Pancreatic ベータ Cell Mass in Diabetic db db Mice
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Abstract
Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic β-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved β-cell mass in db/db mice. The present data suggest that ERW may protects β-cell damage and would be useful for antidiabetic agent.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 30 (2), 234-236, 2007
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679602602368
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- NII Article ID
- 110006162835
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 8616069
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed