Anethole exerts antimetastatic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways
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- Choo Eun Jeong
- College of Oriental Medicine, Kyung Hee University
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- Rhee Yun-Hee
- College of Oriental Medicine, Kyung Hee University
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- Jeong Soo-Jin
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jung
- College of Oriental Medicine, Kyung Hee University
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- Kim Hyun Seok
- Yonsei University School of Medicine
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- Ko Hyun Suk
- College of Oriental Medicine, Kyung Hee University
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- Kim Ji-Hyun
- College of Oriental Medicine, Kyung Hee University
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- Kwon Tae-Rin
- College of Oriental Medicine, Kyung Hee University
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- Jung Ji Hoon
- College of Oriental Medicine, Kyung Hee University
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- Kim Jin Hyoung
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jeong
- College of Oriental Medicine, Kyung Hee University
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- Lee Eun-Ok
- College of Oriental Medicine, Kyung Hee University
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- Kim Dae Keun
- College of Pharmacy, Woosuk University
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- Chen Chang-Yan
- Beth Israel Deaconess Medical Center, Harvard Medical School
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- Kim Sung-Hoon
- College of Oriental Medicine, Kyung Hee University
書誌事項
- タイトル別名
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- Anethole Exerts Antimetatstaic Activity via Inhibition of Matrix Metalloproteinase 2/9 and AKT/Mitogen-Activated Kinase/Nuclear Factor Kappa B Signaling Pathways
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Anethole is known to possess anti-inflammatory and anti-tumor activities and to be a main constituent of fennel, anise, and camphor. In the present study, we evaluated anti-metastatic and apoptotic effects of anethole on highly-metastatic HT-1080 human fibrosarcoma tumor cells. Despite weak cytotoxicity against HT-1080 cells, anethole inhibited the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner. Anethole was also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1. The similar inhibitory effect of anethole on MMP-2 and -9 activities was confirmed by zymography assay. Furthermore, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR). In addition, anethole suppressed the phosphorylation of AKT, extracellular signal-regulated kinase (ERK), p38 and nuclear transcription factor kappa B (NF-κB) in HT-1080 cells. Taken together, our findings indicate that anethole is a potent anti-metastatic drug that functions through inhibiting MMP-2/9 and AKT/mitogen-activated protein kinase (MAPK)/NF-κB signal transducers.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 34 (1), 41-46, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602739712
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- NII論文ID
- 130000402260
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10926704
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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