The Antinociceptive and Anti-inflammatory Action of the CHCl3-Soluble Phase and Its Main Active Component, Damnacanthal, Isolated from the Root of Morinda citrifolia

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  • Okusada Kanako
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Nakamoto Kazuo
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Nishida Mikako
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Fujita-Hamabe Wakako
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Kamiya Kohei
    Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Mizushina Yoshiyuki
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Sciences, Kobe Gakuin University
  • Satake Toshiko
    Department of Pharmacognosy and Natural Product Chemistry, School of Pharmaceutical Sciences, Kobe Gakuin University
  • Tokuyama Shogo
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University

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Morinda citrifolia (Rubiaceae, Noni) is a traditional medicine with various pharmacological activities. We investigated if the MeOH-, CHCl3- and BuOH-soluble phase and its main active component, damnacanthal, isolated from the Noni root, have antinociceptive and anti-inflammatory actions in mice. The CHCl3-soluble phase (3 g/kg, per os (p.o.)) significantly reduced pain-related behavior observed in the formalin test. These effects were not suppressed by pretreatment with naloxone (1 mg/kg, intraperitoneally (i.p.)), an opioid receptor antagonist. The CHCl3-soluble phase (3 g/kg, p.o.) significantly reduced histamine-induced paw edema. The MeOH- and BuOH-soluble phase had no effect in either test. Furthermore, damnacanthal (10—100 mg/kg, p.o.) exerted an antinociceptive effect on chemical nociceptive stimuli, and decreased histamine-induced paw edema. Damnacanthal was weakly bound to the histamine H1 receptor. These data suggest that the CHCl3-soluble phase of the Noni root has antinociceptive and anti-inflammatory effects. Furthermore, these effects of damnacanthal isolated from the Noni root is mediated in part by the histamine H1 receptor.

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