Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells
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- Namekata Iyuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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- Tsuruoka Noriko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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- Tsuneoka Yayoi
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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- Matsuda Tomoyuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Biological Research Laboratories, Nissan Chemical Industries, Ltd.
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- Takahara Akira
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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- Tanaka Yoshio
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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- Suzuki Takeshi
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University School of Material Science, Japan Advanced Institute of Science and Technology (JAIST)
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- Takahashi Tetsuo
- Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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- Iida-Tanaka Naoko
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Department of Food Science, Otsuma Women's University
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- Tanaka Hikaru
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (IKs). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC50 value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 34 (1), 153-155, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679602845952
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- NII論文ID
- 130000402280
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10927048
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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