Differentiation-Inducing Effects of Verticinone, an Isosteroidal Alkaloid Isolated from the Bulbus of Fritillaria ussuriensis, on Human Promyelocytic Leukemia HL-60 Cells.

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  • Pae Hyun-Ock
    Medicinal Resources Research Center of Wonkwang University Department of Microbiology and Immunology, Wonkwang University School of Medicine
  • Oh Hyuncheol
    Professional Graduate School of Oriental Medicine, Wonkwang University
  • Choi Byung-Min
    Medicinal Resources Research Center of Wonkwang University Department of Microbiology and Immunology, Wonkwang University School of Medicine
  • Oh Gi-Su
    Medicinal Resources Research Center of Wonkwang University Department of Microbiology and Immunology, Wonkwang University School of Medicine
  • Paik Sang-Gi
    Department of Biology, College of Natural Science, Chungnam National University
  • Jeong Sejin
    Medicinal Resources Research Center of Wonkwang University Department of Microbiology and Immunology, Wonkwang University School of Medicine
  • Hwang Kee-Myoung
    Department of Microbiology and Immunology, Wonkwang University School of Medicine
  • Yun Young-Gab
    Medicinal Resources Research Center of Wonkwang University
  • Chung Hun-Taeg
    Medicinal Resources Research Center of Wonkwang University Department of Microbiology and Immunology, Wonkwang University School of Medicine

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The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.

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