2'-O,4'-C-Ethylene-Bridged Nucleic Acids (ENA) as Next-Generation Antisense and Antigene Agents
-
- Koizumi Makoto
- Lead Discovery Research Laboratories, Sankyo Co., Ltd.
Search this article
Abstract
Novel 2′-O,4′-C-ethylene nucleosides have been synthesized as building blocks for antisense and antigene oligonucleotides. 2′-O,4′-C-Ethylene-bridged nucleic acids (ENATM) comprising 2′-O,4′-C-ethylene nucleosides have considerable affinity to complementary RNA and double-stranded DNA. Incorporation of 2′-O,4′-C-ethylene nucleosides into oligonucleotides dramatically increase their resistance against exonucleases. In this review, the properties of ENA oligonucleotides and some of their applications as antisense and antigene oligonucleotides are described.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 27 (4), 453-456, 2004
The Pharmaceutical Society of Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679603086592
-
- NII Article ID
- 110003608785
-
- NII Book ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL BIB ID
- 6896717
-
- PubMed
- 15056846
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed