TGF-β/SMAD Signaling and lts lnvolvement in Tumor Progression
書誌事項
- タイトル別名
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- TGF-.BETA./SMAD Signaling and Its Involvement in Tumor Progression.
- TGF ベータ SMAD Signaling and lts lnvolvement in Tumor Progression
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説明
Cytokines of the transforming growth factor-β(TGF-β) superfamily are multifunctional peptides that regulate growth and differentiation of various types of cells. Members of the TGF-β superfamily bind to type II and type I serine/threonine kinase receptors, which mediate intracellular signals through SMAD proteins. Of 3 subtypes of SMADs, receptor-regulated SMADs are phosphorylated by the serine/threonine kinase receptors, form complexes with common-mediator SMAD, and move into the nucleus, where they act as components of transcription factor complexes. Abnormalities of the TGF-β receptors and SMADs have been detected in various tumors, including colorectal cancers and pancreatic cancers. Inhibitory SMADs and transcriptional co-repressors, including c-Ski and SnoN, repress the TGF-β/SMAD signaling. Perturbation of the TGF-β/SMAD signaling pathway may result in progression of tumors through resistance of the cells to the growth inhibition induced by TGF-β.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 23 (10), 1125-1130, 2000
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603248512
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- NII論文ID
- 110003639840
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 5506418
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- PubMed
- 11041237
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可