Effects of Dermatan and Dextran Sulfates on Arginine Amidase Activity Released from Isolated Rabbit Arteries.
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- TAKEUCHI Koichi
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- MIYAZAKI Kyousuke
- Seikagaku Kogyo Co.
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- ISHI-NOZAWA Reiko
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- CHIBA Ryoko
- Laboratory of Analytical Chemistry of Medicines, Showa College of Pharmaceutical Sciences
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- SHIMOKAWA Ken-ichi
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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- KATAYAMA Masatoki
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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- MATSUDA Yoshifumi
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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We examined the levels of arginine amidase secreted from isolated rabbit arteries treated with dermatan and dextran sulfates, and the relation between the secretion of arginine amidase activity and the concentration of dermatan sulfate added to these arteries. The results showed that while dextran sulfate tended to accelerate the release of arginine amidase activity from the isolated rabbit ear artery, the induction was not significant. There was a significant increase in the level of arginine amidase released from the lower portion of isolated rabbit aorta (p<0.05), but no significant change in the upper portion of the aorta. In contrast, the addition of dermatan sulfate significantly increased the level of arginine amidase activity released from the isolated rabbit ear artery and the upper and lower portions of the aorta (p<0.05). Linear dose-response relationships were observed between the level of arginine amidase activity released from the isolated rabbit ear artery and aorta and the concentration of dermatan sulfate added.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 24 (5), 465-469, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603318528
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- NII論文ID
- 110003638493
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXjt1alsb0%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 5763854
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- PubMed
- 11379761
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可