Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis
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- Chi Yu-Ming
- Seiwa Pharmaceutical, Ltd.
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- Nakamura Motoyuki
- Seiwa Pharmaceutical, Ltd.
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- Yoshizawa Toyokichi
- Seiwa Pharmaceutical, Ltd.
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- Zhao Xi-Ying
- Seiwa Pharmaceutical, Ltd.
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- Yan Wen-Mei
- Beijing University of Traditional Chinese Medicine and Pharmacy
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- Hashimoto Fumio
- Faculty of Pharmaceutical Sciences, Kumamoto University
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- Kinjo Junei
- Faculty of Pharmaceutical Sciences, Kumamoto University
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- Nohara Toshihiro
- Faculty of Pharmaceutical Sciences, Kumamoto University
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Abstract
To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 28 (10), 1989-1991, 2005
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679603351936
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- NII Article ID
- 110003666380
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 7453365
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- PubMed
- 16204962
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed