Human Intestinal Bacterium, Strain END-2 Is Responsible for Demethylation as Well as Lactonization during Plant Lignan Metabolism

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  • Jin Jong-Sik
    Institute of Natural Medicine, University of Toyama Benno Laboratory, Center for Intellectual Property Strategies, RIKEN
  • Hattori Masao
    Institute of Natural Medicine, University of Toyama

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Abstract

A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (−)-secoisolariciresinol to (+)-ENL and (−)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.

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