Novel phthalide compounds from Sparassis crispa (Hanabiratake), hanabiratakelide A-C, exhibiting anti-cancer related activity
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- Yoshikawa Kazuko
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Kokudo Naoki
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Hashimoto Toshihiro
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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- Yamamoto Kyosuke
- Research & Development Center, Unitika Ltd.
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- Inose Toshiaki
- Research & Development Center, Unitika Ltd.
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- Kimura Takashi
- Research & Development Center, Unitika Ltd.
書誌事項
- タイトル別名
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- Novel Phthalide Compounds from <i>Sparassis crispa</i> (Hanabiratake), Hanabiratakelide A—C, Exhibiting Anti-cancer Related Activity
- Novel Phthalide Compounds from <i>Sparassis crispa</i> (Hanabiratake), Hanabiratakelide A—C, Exhibiting Anti-cancer Related Activity
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抄録
Sparassis crispa (SC), known as Hanabiratake in Japanese, is an edible mushroom with various medicinal properties. We isolated 3 novel phthalides, designated hanabiratakelide A (1), B (2), and C (3), from the SC fruit body. In this investigation, 3 known phthalides (4—6), ubiquinone-9, and 2 known unsaturated fatty acids were also isolated. Their structures were elucidated primarily through extensive NMR experiments. The isolated compounds 1—6 were tested for their anti-oxidant activity. The in vitro superoxide dismutase-like activity of the 3 hanabiratakelides was stronger than that of vitamin C. The compounds also exerted inhibitory effects on lipopolysaccharide-stimulated nitric oxide and prostaglandin E2 production by a murine macrophage cell line, RAW264. In addition, the growth of the colon cancer cell lines Caco-2 and colon-26 was significantly inhibited by treatment with the 3 hanabiratakelides. In vivo, the frequency of azoxymethane-induced aberrant crypt foci was reduced in SC-fed F344/N rats compared to rats fed a standard diet. In conclusion, 3 novel phthalides, hanabiratakelides, derived from SC were shown to possess anti-oxidant, anti-inflammatory, and anti-tumor activity.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (8), 1355-1359, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603403520
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- NII論文ID
- 130000300360
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10764620
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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