Reduction in intraocular pressure by the instillation of eye drops containing disulfiram included with 2-hydroxypropyl-β-cyclodextrin in rabbit
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- Ito Yoshimasa
- Faculty of Pharmacy, Kinki University Pharmaceutical Research and Technology Institute, Kinki University
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- Nagai Noriaki
- Faculty of Pharmacy, Kinki University
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- Shimomura Yoshikazu
- Department of Ophthalmology, Kinki University School of Medicine
書誌事項
- タイトル別名
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- Reduction in Intraocular Pressure by the Instillation of Eye Drops Containing Disulfiram Included with 2-Hydroxypropyl-.BETA.-cyclodextrin in Rabbit
- Reduction in intraocular pressure by the instillation of eye drops containing disulfiram included with 2 hydroxypropyl v cyclodextrin in rabbit
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抄録
We have studied the effect of disulfiram (DSF) solution containing 2-hydroxypropyl-β-cyclodextrin and hydroxypropylmethylcellulose (DSF eye drops) on intraocular pressure (IOP) in experimentally induced ocular hypertension in rabbits. In both in vitro and in vivo transcorneal penetration experiments using rabbit corneas, only diethyldithiocarbamate (DDC) was detected in the aqueous humor, while DSF was not detected. The amount of DDC penetration for 0.25% DSF eye drops was about 4-fold that for 0.1% DSF eye drops in in vivo transcorneal penetration experiments. The elevation in IOP was induced by the rapid infusion of 5% glucose solution (15 ml/kg of body weight) through the marginal ear vein, and IOP was measured with an electronic tonometer. The induced elevation in IOP was reduced by the instillation of 0.1—0.5% DSF eye drops, and the IOP-reducing effect increased with the increase in DSF concentration in the drops. Nitric oxide (NO) levels increased in the aqueous humor following the infusion of the 5% glucose solution, and this increase was also suppressed by the instillation of DSF eye drops. In conclusion, the present study demonstrates that the instillation of DSF eye drops has an IOP-reducing effect in rabbits with experimentally induced ocular hypertension, probably caused by the suppression of NO production.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (9), 1574-1578, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603412096
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- NII論文ID
- 130000322359
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10796976
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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