Specific Alternation of Rhythm in Temperature (SART) Stress-Induced Irritable Bowel Syndrome-Like Changes in Mice and Effects of Drugs
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- Funakami Yoshinori
- Faculty of Pharmacy, Kinki University
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- Itoh Eiji
- Faculty of Pharmacy, Kinki University
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- Hata Taeko
- Faculty of Pharmacy, Kinki University
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- Wada Tetsuyuki
- Faculty of Pharmacy, Kinki University
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- Ichida Seiji
- Faculty of Pharmacy, Kinki University
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Stress is closely associated with the manifestation and progress of irritable bowel syndrome (IBS). For the purpose of establishing experimentally the relationship between IBS and stress, the transportation capacity of the small intestine in specific alternation of rhythm in temperature (SART)-stressed animals was studied using charcoal transportation method. The charcoal suspension was administered orally into the stomach of fasting mice. Mice were sacrificed after a certain time and %charcoal transit (%CT) of the small intestine was measured. The %CTs in SART-stressed mice were greater than those in unstressed or continuously cold-stressed mice. This increase in %CT remained for 1 week after discontinuation of SART stress loading. Cholinergic blockers decreased %CTs in SART-stressed mice. Increases in %CT by a cholinesterase inhibitor were less in SART-stressed mice than in unstressed mice. Increases of %CT in SART-stressed mice were suppressed by Neurotropine. These results suggested that the parasympathetic hypertonicity, not just cold, played a role in the increases in the transportation capacity in SART-stressed mice and that these animals can be a useful tool for elucidation of the mechanism of IBS.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (9), 1545-1549, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603422720
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- NII論文ID
- 130000322354
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10796919
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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