In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents
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- Shin Yong-Wook
- College of Pharmacy, Kyung Hee University
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- Bae Eun-Ah
- College of Pharmacy, Kyung Hee University
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- Cai Xing Fu
- Korea Research Institute of Bioscience and Biotechnology
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- Lee Jung Joon
- Korea Research Institute of Bioscience and Biotechnology
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- Kim Dong-Hyun
- College of Pharmacy, Kyung Hee University
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Abstract
The unripe fruit of Evodia rutaecarpa (JUSS) BENTH (ER, Family Rutaceae) has been used frequently as a traditional medicine against inflammatory diseases in Korea, China and Japan. To evaluate antiallergic effect of ER, we isolated its main constituents, evodiamine and rutaecarpine, and evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors by compound 48/80. ER and its constituents, evodiamine and rutaecarpine, potently inhibited PCA reaction and scratching behaviors in mice, although ER weakly inhibited scratching behaviors. Evodiamine and rutaecarpine inhibited TNF-α and IL-4 protein expression in RBL-2H3 cells induced by IgE–antigen complex, although these did not inhibit degranulation of RBL-2H3 cells induced by IgE–antigen complex and rat peritoneal mast cells induced by compound 48/80. These findings suggest that ER and its constituents, evodiamine and rutaecarpine, may be effective for IgE-induced allergic diseases such as atopic dermatitis and rhinitis.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 30 (1), 197-199, 2007
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679603672704
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- NII Article ID
- 110006153294
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 8590560
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed