[1-11C]Octanoate as a PET Tracer for Studying Ischemic Stroke. Evaluation in a Canine Model of Thromboembolic Stroke with Positron Emission Tomography.

DOI Web Site Web Site PubMed 参考文献26件 オープンアクセス

この論文をさがす

説明

Octanoate is taken up by the brain and converted in astrocytes to glutamine through the TCA cycle after β-oxidation. Consequently, [111C]octanoate might serve as a useful positron emission tomography (PET) probe for studying cerebral oxidative metabolism and/or astroglial functions. The present study attempted to evaluate the utility of using [111C]octanoate as a PET tracer for imaging and evaluating the pathopysiology of ischemic stroke. We used a canine model of thromboembolic stroke. Five male beagle dogs were implanted with an indwelling catheter in the left internal carotid artery. A single autologous blood clot was injected into the left internal carotid artery through the catheter. The brain distribution of [111C]octanoate and cerebral blood flow (CBF) were determined 24 h after insult using a high resolution PET scanner. Post mortem brain regions unstained with 2, 3, 5-triphenyltetrazolium chloride (TTC) were defined as infarcts. In the region of an infarct, accumulation of [111C]octanoate decreased concurrently with CBF reduction. In contrast, normal accumulation of [111C]octanoate was observed in ischemic but vital regions, suggesting that an increased accumulation of [111C]octanoate relative to CBF takes place in these regions. In conclusion, [111C]octanoate accumulated in ischemic but vital retions, indicating that [111C]octanoate is potentially useful PET tracer for imaging and evaluating the pathophysiology of ischemic stroke.

収録刊行物

参考文献 (26)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ