Protective Effect of Fluvastatin on Degradation of Apolipoprotein B by a Radical Reaction in Human Plasma.

DOI Web Site Web Site PubMed 被引用文献1件 参考文献53件 オープンアクセス

この論文をさがす

説明

Fluvastatin, which is a synthetic 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, its metabolites (M2, M3 and M4) and trolox all inhibited the decrease of apolipoprotein B-100 (apoB) and α-tocopherol in a radical reaction of human plasma initiated by Cu2+. The concentrations of fluvastatin, M2, M3, M4 and trolox for 50% inhibition (IC50) of apoB fragmentation were 405, 8.55, 1.75, 305, and 43.4 μM, respectively. The IC50 value of pravastatin, which is another HMG-CoA reductase inhibitor, was 2880 μM, showing that pravastatin is not an effective antioxidant. Although fluvastatin, its metabolites and trolox inhibited the decrease of α-tocopherol in a similar manner to that of apoB, pravastatin did not significantly inhibit the decrease of α-tocopherol. Since oxidation of low density lipopotein (LDL) is an important step in the initiation and progression of atherosclerosis, fluvastatin may reduce the risk of atherosclerosis not only by lowering plasma cholesterol but also by protecting LDL from oxidation.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (53)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ