Decursin Prevents Cisplatin-Induced Apoptosis via the Enhancement of Antioxidant Enzymes in Human Renal Epithelial Cells
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- Kim Jeong Hwan
- College of Oriental Medicine, Kyung Hee University
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- Jeong Soo-Jin
- College of Oriental Medicine, Kyung Hee University
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- Kwon Hee-Young
- College of Oriental Medicine, Kyung Hee University
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- Park Sang Yoon
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jung
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jeong
- College of Oriental Medicine, Kyung Hee University
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- Lieske John Charles
- Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine
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- Kim Sung-Hoon
- College of Oriental Medicine, Kyung Hee University
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抄録
Adverse effects, nephrotoxicity and hepatotoxicity, of anticancer drugs such as cisplatin have limited the usage for cancer therapy. Therefore, development or identification of supplement agents in anticancer drugs is attractive to reduce side effects and enhance antitumor activity. Here, we found that decursin isolated from Angelica gigas showed protective effects of cisplatin-induced damage in normal human primary renal epithelial cells (HRCs). We found that decursin significantly blocked cisplatin-induced cytotoxicity by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assay in HRCs. Further, we found that decursin inhibited sub-G1 and cell death by suppression of cleavage of caspase-3, -9 and poly(ADP-ribose) polymerase (PARP) induced by cisplatin treatment in HRCs. Importantly, decursin effectively restored the activities of Cu/Zn superoxide dismutase (SOD), catalase and glutathione peroxidase in cisplatin-treated HRCs. Taken together, our findings demonstrate that decurcin prevents cisplatin-induced cytotoxicity and apoptosis through the activation of antioxidant enzymes in HRCs and suggest further that combination of decursin might suppressed adverse effects of anticancer drugs in cancer patients.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (8), 1279-1284, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603777536
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- NII論文ID
- 130000300348
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3cjis1GqsA%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10764442
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- PubMed
- 20686219
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可