Passive Cutaneous Anaphylaxis-Inhibitory Action of Tectorigenin, a Metabolite of Tectoridin by Intestinal Microflora
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- Park Eun-Kyung
- Department of Biochemistry, Kon Kuk University
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- Shin Yong-Wook
- College of Pharmacy, Kyung Hee University
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- Lee Hae-Ung
- College of Pharmacy, Kyung Hee University
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- Lee Chang Soo
- Department of Biochemistry, Kon Kuk University
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- Kim Dong-Hyun
- Department of Biochemistry, Kon Kuk University
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Abstract
Tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae) are metabolized to tectorigenin by human intestinal microflora. When tectoridin was orally administered to rats, tectorigenin, but not tectoridin, was detected in urine after β-glucuronidase hydrolysis. The main metabolite tectorigenin potently inhibited the passive cutaneous anaphylaxis reaction and inhibited in vitro the release of β-hexosaminidase from RBL-2H3 cells induced by IgE. These results suggest that tectoridin is a prodrug, which can be transformed into the active agent tectorigenin by human intestinal bacteria and can be a candidate for antiallergic agent.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 27 (7), 1099-1102, 2004
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679603878912
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- NII Article ID
- 110003608920
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6986811
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- PubMed
- 15256747
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed
