The 5-HT1A Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT2A Receptor Hyperfunction in Rats: Involvement of 5-HT1A Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats

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  • Kitamura Yoshihisa
    Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Department of Hospital Pharmacy, Okayama University Medical School
  • Kitagawa Kouhei
    Department of Hospital Pharmacy, Okayama University Medical School
  • Fujitani Yoshika
    Department of Hospital Pharmacy, Okayama University Medical School
  • Shibata Kazuhiko
    Department of Hospital Pharmacy, Okayama University Medical School
  • Araki Hiroaki
    Division of Hospital Pharmacy, Ehime University Medical School
  • Sendou Toshiaki
    Department of Hospital Pharmacy, Okayama University Medical School
  • Gomita Yutaka
    Department of Hospital Pharmacy, Okayama University Medical School

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  • 5 HT1A Receptor Full Agonist 8 OH DPAT Inhibits ACTH Induced 5 HT2A Receptor Hyperfunction in Rats Involvement of 5 HT1A Receptors in the DOI Induced Wet Dog Shakes in ACTH Treated Rats

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We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT1A receptor system; however, the inhibitory effects from the 5-HT1A receptors to the 5-HT2A receptor system is not inhibited in ACTH-treated rats.

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