Difference in Subcellular Distribution between 45- and 37-kDa Mevalonate Pyrophosphate Decarboxylase in Rat Liver.
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- MICHIHARA Akihiro
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- SAWAMURA Makoto
- Takeda Hospital
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- YAMORI Yukio
- Graduate School of Human and Environmental Studies, Kyoto University
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- AKASAKI Kenji
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- TSUJI Hiroshi
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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We previously reported that the CP diet (a diet containing 5% cholestyramine and 0.1% pravastatin)-induced new species of 37-kDa mevalonate pyrophosphate decarboxylase (MPD) was characteristically and immunologically very similar to the well-known 45-kDa MPD. In the present study, we found a difference in subcellular distribution between 45- and 37-kDa MPD by cell fractionation and immunoblot analysis. The cytosol fraction contained 45- and 37-kDa MPD. Peroxisomal fraction contained a small amount of 45-kDa MPD, but not 37-kDa MPD. Also, 45-kDa MPD in peroxisome is localized in the matrix. From these data, the difference in subcellular distribution between 45- and 37-kDa MPD may be due to differences in the physiological role of cholesterol biosynthesis in rat liver.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 24 (12), 1347-1350, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603955328
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- NII論文ID
- 110003638417
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXosl2ku78%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 5995671
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- PubMed
- 11767099
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可