Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis.
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- KINJO Junei
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- NAGAO Tsuneatsu
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- TANAKA Takashi
- School of Pharmaceutical Sciences, Nagasaki University
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- NONAKA Gen-ichiro
- Usaien Pharm. Co., Ltd.
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- OKABE Hikaru
- Faculty of Pharmaceutical Sciences, Fukuoka University
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Abstract
The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma [MK-1, 50% growth inhibition (GI50): 25 μg/ml], human uterus carcinoma (HeLa, GI50: 30 μg/ml), and murine melanoma (B16F10, GI50: 8 μg/ml) cells. Bioactivity-guided fractionation resulted in the isolation of gallic acid methylester (1), gallic acid (2), 7-O-galloylcatechin (3), 1,6-di-O-galloylglucose (4), 1-O-galloylglucose (5), and trigalloylgallic acid (6), and their antiproliferative activity was estimated. All showed much stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Compound 2 and its tetramer (6) with a free carboxyl group showed higher activity than those which did not have a free carboxyl group. In relation to the gallic acid tetramer (6), two gallic acid dimers (ellagic acid and dehydrodigallic acid) and trimers (tergallic acid dilactone and flavogallonic acid dilactone) were tested for their activity, and compared with those of the isolates.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 24 (12), 1443-1445, 2001
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679603959552
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- NII Article ID
- 110003638439
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXosl2rs7o%3D
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 10069/8375
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- NDL BIB ID
- 5995943
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- PubMed
- 11767121
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed