The 5-HT2C/2B Receptor Agonist m-Chlorophenylpiperazine (mCPP) Inhibits 2-Deoxy-D-glucose (2-DG)-Induced Hyperphagia in Rats.
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- SUGIMOTO Yumi
- Department of Pharmacology, Kobe Pharmaceutical University
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- YOSHIKAWA Tomoko
- Department of Pharmacology, Kobe Pharmaceutical University
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- NOMA Toshiko
- Department of Pharmacology, Kobe Pharmaceutical University
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- YAMADA Jun
- Department of Pharmacology, Kobe Pharmaceutical University
書誌事項
- タイトル別名
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- 5 HT2C 2B Receptor Agonist m Chlorophenylpiperazine mCPP Inhibits 2 Deoxy D glucose 2 DG Induced Hyperphagia in Rats
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Effects of the 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) on hyperphagia elicited by 2-deoxy-D-glucose (2-DG) were investigated in rats. mCPP apparently reduced 2-DG-induced hyperphagia. Suppressive effects of mCPP on hyperphagia induced by 2-DG were inhibited by the 5-HT2A/2B/2C receptor antagonist, ritanserin, although the 5-HT2A receptor antagonist ketanserin was without effect. Thus, inhibitory effects of mCPP on 2-DG-induced hyperphagia are mediated by the 5-HT2C/2B receptor. Our results demonstrate that mCPP can inhibit the bulimia model, 2-DG-induced hyperphagia.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 24 (12), 1431-1433, 2001
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679603964800
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- NII論文ID
- 110003638435
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3MXosl2rs74%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 5995884
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- PubMed
- 11767117
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可