Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases
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- Kim Seung-Ae
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Lee Hyo-Jeong
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Ahn Kwang Seok
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Lee Hyo-Jung
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Lee Eun-Ok
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Ahn Kyoo-Seok
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Choi Seung-Hoon
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Jung Soo-Jin
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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- Kim Ji Young
- Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyunghee University
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- Baek Namin
- Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyunghee University
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- Kim Sung-Hoon
- Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University
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抄録
Paeonol (2′-hydroxy-4′-methoxyacetophenone) is known to possess anti-inflammatory and anti-proliferative activities. Recently there is evidence that anti-inflammatory agents may be useful in the setting of angiogenesis-related diseases. Thus in the present study the anti-angiogenic activity of paeonol and its mechanism were investigated in vitro and in vivo. Paeonol significantly inhibited proliferation of basic fibroblast growth factor (bFGF)-stimulated human umbilical vein endothelial cells (HUVECs). Paeonol also significantly inhibited migration and tube formation of bFGF-stimulated HUVECs in vitro. In addition, paeonol significantly suppressed neovessel formation on bFGF-treated chick chorioallantoic membrane (CAM) and disrupted bFGF-induced neovascularization in Matrigel plug assay in vivo. Furthermore, paeonol downregluated Akt phosphorylation in bFGF-stimulated HUVECs and reduced expression of matrix metalloproteinases-2 and -9 in HT1080 human fibrosarcoma cells. The Akt inhibitor LY294002 synergistically potentiated paeonol-induced inactivation of Akt and vascular endothelial growth factor in bFGF-treated HUVECs. Taken together, these findings suggest that paeonol can be a potent suppressor of angiogenesis and metastasis partially through inhibition of Akt signaling pathway and matrix metalloproteinase activity.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 32 (7), 1142-1147, 2009
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604072832
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- NII論文ID
- 130000117207
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10264104
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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