Reproductive Effects of Ethnomedicinal Formulation of Tape-Vine Leaves in Female Rats
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- Mukherjee Subhendu
- Department of Chemical Technology, University of Calcutta
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- Banerjee Rita
- Pharmacology Research Unit, Central Research Institute (Ayurveda)
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- Upadhyay Sachchida Nand
- Pharmacology Research Unit, Central Research Institute (Ayurveda)
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- Hazra Jayram
- Pharmacology Research Unit, Central Research Institute (Ayurveda)
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- Poddar Kashi Nath
- Clinical Laboratory
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- Mukherjee Arup
- Department of Chemical Technology, University of Calcutta
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- Saha Achintya
- Department of Chemical Technology, University of Calcutta
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Documented ethno-contraceptive use of Tape-vine or Stephania japonica (THUNB.) MIERS., Syn. Stephania hernandifolia (WILLD.) WALP. leaves is evaluated with regards to post-coital pregnancy interceptive activity of its aqueous extract (AE) and an ethnomedicinal formulation (EF) in Wistar rats. EF at 500 and 250 mg/kg doses induced 66.7% and 33.3% post-coital pregnancy interception respectively and the higher dose exhibited significant reduction in number of litters born and also anti-implantation property. In contrast, none of the dose levels of AE interfered in pregnancy but significant anti-implantation property was observed at doses of 2 and 1 g/kg, even as the higher dose produced significant reduction in number of litters born as well. EF at 500 mg/kg also exhibited significant uterotrophic activity and histological changes in uterus. Pair-wise comparison of sex hormone-levels exhibited significant increment in serum estradiol, LH and FSH but decrease in progesterone levels. Assessed blood lipid-carbohydrate profile exhibited substantial decrease in glucose, cholesterol, VLDL and triglyceride contents and significant increase in HDL. It is concluded that EF probably acts as better post-coital pregnancy interceptive agent through restriction of implantation by alteration of gonadal hormone levels and decline in blood-glucose levels that possibly disrupts oxidative energy metabolism in uterus during implantation. High surge in LH and FSH suggests negligible interference in ovulatory mechanism. This preparation also seems to be free of cardiovascular risk factors. HPTLC and HPLC analysis of both EF and AE exhibited marked chemical differences.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 29 (9), 1916-1922, 2006
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詳細情報 詳細情報について
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- CRID
- 1390282679604136576
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- NII論文ID
- 110005602361
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8026637
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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