Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken

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  • He Chang-Liang
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University
  • Fu Ben-Dong
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University
  • Shen Hai-Qing
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University
  • Jiang Xiao-Lin
    Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture
  • Zhang Chang-Shuai
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University
  • Wu Shuai-Cheng
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University
  • Zhu Wei
    College of Animal Science, Guizhou University
  • Wei Xu-Bin
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University

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Xiang-Qi-Tang (XQT) is a Chinese herbal formula containing Rhizoma Cyperi, Andrographis paniculata and Astragalus membranaceus. The present study investigated the effects of XQT on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic Escherichia coli (APEC). To detect the effect of XQT, the chickens were pretreated with the formula 12 h before being challenged with 108 colony forming unit (CFU) of APEC. The results showed that 0.6 g/kg XQT significantly elevated the survival rate of infected chickens. To further investigate the mechanism of decreasing mortality of XQT, we examined plasma inflammatory mediator levels. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and soluble endothelial protein C receptor (sEPCR) were significantly increased in chickens challenged with APEC alone, whereas chickens pretreated with 0.6 g/kg XQT showed marked decrease of these inflammatory mediator levels during the death peak. Taken together, this study demonstrates that XQT has protective effects in APEC-treated chickens. The action mechanisms of XQT involve anti-inflammation and antithrombotic activity. These findings may contribute to future research on the action mechanisms of this formula, as well as prevention of or therapy for avian colibacillosis.

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