The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus
-
- Oh Myung Sook
- College of Oriental Medicine, Kyung Hee University
-
- Park Chan
- College of Medicine, Kyung Hee University
-
- Huh Youngbuhm
- College of Medicine, Kyung Hee University
-
- Kim Hong-Yeoul
- Institute of Oriental Medicine, Kyung Hee University
-
- Kim Hocheol
- College of Oriental Medicine, Kyung Hee University
-
- Kim Hyung-Min
- College of Oriental Medicine, Kyung Hee University
-
- Bae Hyunsu
- College of Oriental Medicine, Kyung Hee University
-
- Ahn Duk Kyun
- Jaseng Research Institute of Bio-technology and Bioscience
-
- Park Wan-Su
- College of Oriental Medicine, Kyung Hee University
-
- Park Seong Kyu
- College of Oriental Medicine, Kyung Hee University
Bibliographic Information
- Other Title
-
- Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus
Search this article
Abstract
BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64±39.88 vs. 73.08±29.30 s, respectively; n=11; p<0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07±151.16 vs. 818.01±132.98 cells per DG, respectively; n=11; p<0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 29 (4), 813-816, 2006
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679604293888
-
- NII Article ID
- 110005602193
-
- NII Book ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL BIB ID
- 7862074
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed