The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper(II)

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  • Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper 2

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Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper(II) ion (Cu2+) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carbon-centered radicals) generated from reaction of DHPs with Cu2+.

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