Recent Progress in .ALPHA.1-Adrenoceptor Pharmacology.

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  • Koshimizu Taka-aki
    Department of Molecular, Cell Pharmacology, National Children's Medical Research Center
  • Yamauchi Junji
    Department of Molecular, Cell Pharmacology, National Children's Medical Research Center
  • Hirasawa Akira
    Department of Molecular, Cell Pharmacology, National Children's Medical Research Center
  • Tanoue Akito
    Department of Molecular, Cell Pharmacology, National Children's Medical Research Center
  • Tsujimoto Gozoh
    Department of Molecular, Cell Pharmacology, National Children's Medical Research Center

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  • Recent Progress in α1-Adrenoceptor Pharmacology
  • Recent Progress in アルファ 1 Adrenoceptor Pharmacology

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The adrenoceptors (ARs) play a key role in the modulation of sympathetic nervous system activity and are a site of action for many clinically important therapeutic agents. The α1-adrenoceptor subtypes (α1A-, α1B-, and α1D-AR) play a prominent role in regulating vascular tone and hypertrophic growth of smooth muscle and cardiac cells. Their functional characteristics with respect to ligand binding and second messenger utilization have been well described. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of α1-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the α1-ARs.

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