Metabolite Profiles of Flutamide in Serum from Patients with Flutamide-Induced Hepatic Dysfunction
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- Takashima Eiji
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Iguchi Kazuhiro
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Usui Shigeyuki
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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- Yamamoto Hajime
- Toyama Prefectural Central Hospital
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- Hirano Kazuyuki
- Laboratory of Pharmaceutics, Gifu Pharmaceutical University
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Abstract
Hepatic dysfunction due to flutamide administration has been reported and this side effect often limits the use of the agent. The prediction of flutamide-induced hepatotoxicity is attributed to the proper use of the antiandrogen. In this study, we investigated whether hepatic dysfunction could be assessed by the metabolite profile in serum from patients receiving this drug. Serum samples were obtained from 15 patients with prostate cancer, 12 patients with no sign of hepatotoxicity and 3 patients with slight hepatic dysfunction during long-term flutamide treatment. We analyzed the metabolite profiles by LC/MS in selected ion monitoring mode and detected a new metabolite (M3) that was an oxidation product of flutamide. However, there were no consistent differences in the serum flutamide metabolites between patients with normal function and those suffering hepatic dysfunction. The metabolite profiles in the β-glucuronidase-treated serum showed a similar pattern between normal functioning and dysfunctional groups. Thus, the profile of flutamide metabolites determined in serum may not contribute to the risk prediction of flutamide-related hepatotoxicity.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 26 (10), 1455-1460, 2003
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679604398336
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- NII Article ID
- 110003608324
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6696595
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- PubMed
- 14519954
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed