Effects of Kangen-karyu on Coagulation System and Platelet Aggregation in Mice.
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- Makino Toshiaki
- Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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- Wakushima Hannosuke
- Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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- Okamoto Takuya
- Department of Kampo Medicinal Science, Hokkaido College of Pharmacy Iskura Industry Co., Ltd.
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- Okukubo Yasuhiro
- Iskura Industry Co., Ltd.
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- Saito Ken-ichi
- Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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- Kano Yoshihiro
- Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
この論文をさがす
説明
Kangen-karyu (KGK) is a herbal formula created under the theory of traditional Chinese herbal medicine to invigorate the blood and dispel blood stasis. It contains 6 herbs: peony root, cnidium rhizome, safflower, cyperus rhizome, saussurea root (JP XIV), and Salvia miltiorrhiza root. The present study has been conducted to evaluate the in vivo anti-thrombotic activity of KGK using normal mice. Three consecutive days of oral administration of KGK to mice significantly extended tail-bleeding time and suppressed ex vivo platelet aggregation, while it did not extend the prothrombin time of plasma. It was revealed that the anti-thrombotic effects of KGK did not depend on the downregulation of the coagulation system, but depended in part on the inhibition of platelet aggregation. These results explain one of the pharmacological activities of KGK to invigorate the blood and dispel blood stasis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 25 (4), 523-525, 2002
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604416128
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- NII論文ID
- 110003638815
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD38XkslWrsLY%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6121143
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- PubMed
- 11995937
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可