Relationship between Cisplatin or Nedaplatin-Induced Nephrotoxicity and Renal Accumulation

DOI Web Site Web Site PubMed 被引用文献12件 参考文献41件 オープンアクセス
  • Kawai Yoshiko
    Division of Pharmacology, Osaka University of Pharmaceutical Sciences
  • Taniuchi Saburo
    Division of Pharmacology, Osaka University of Pharmaceutical Sciences
  • Okahara Shigeki
    Division of Pharmacology, Osaka University of Pharmaceutical Sciences
  • Nakamura Masuhisa
    Division of Pharmacology, Osaka University of Pharmaceutical Sciences
  • Gemba Munekazu
    Division of Pharmacology, Osaka University of Pharmaceutical Sciences

書誌事項

公開日
2005
資源種別
journal article
DOI
  • 10.1248/bpb.28.1385
公開者
公益社団法人 日本薬学会

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説明

Nedaplatin is known to exhibit antitumor activity similar to that of cisplatin. However, concerning side effects, nedaplatin causes renal toxicity less frequently than cisplatin. In this study, we compared the incidence of renal toxicity between cisplatin and nedaplatin by investigating the difference in kidney tissue accumulation. Kidney tissue accumulation of cisplatin administered at 3.75 mg/kg was similar to that of nedaplatin administered at 24 mg/kg. At these doses, the plasma creatinine level and urinary excretion of glucose and N-acetyl-β-D-glucosaminidase (NAG) similarly increased. There was a correlation between kidney accumulation of cisplatin and nedaplatin and the increases in plasma creatinine level and urinary excretion of NAG. Therefore, our results suggest that nedaplatin less frequently causes renal toxicity in comparison to cisplatin due to lower kidney accumulation.

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