The Immune-Enhancing Effect of the Herbal Combination Bouum-Myunyuk-Dan

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  • Jeong Hyun-Ja
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University
  • Chung Hwan-Suck
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University
  • An Hyo-Jin
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University
  • Seo Sang-Wan
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University
  • Kim Tae-gyun
    College of Oriental Medicine, Wonkwang University
  • Won Jin-Hee
    College of Oriental Medicine, Wonkwang University
  • Shin Jo-Young
    College of Oriental Medicine, Wonkwang University
  • Ahn Kyoo-Seok
    Department of Pathology, College of Oriental Medicine, Kyung Hee University
  • Kim Hyung-Min
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University

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タイトル別名
  • Immune Enhancing Effect of the Herbal Combination Bouum Myunyuk Dan

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説明

The herbal formulation Bouum-Myunyuk-Dan (BMD) has long been used for various diseases. It has been shown to have antimicrobial and anti viral activity clinically. However, it is still unclear how BMD exerts these effects in experimental models. In this study, we investigated the effect of BMD on the production of cytokines in a human T cell line, MOLT-4 cells, and in mouse peritoneal macrophages. As a result, BMD significantly increased the viability and proliferation of splenocytes (p<0.05) and also significantly increased interleukin (IL)-2 and IL-4 production compared with media control (about 2.7-fold for IL-2 and 6.7-fold for IL-4, p<0.05) after 24 h. BMD increased the interferon (IFN)-γ production by 3.7-fold but there were no significant differences compared with controls. Maximal effective concentrations of BMD were 1 mg/ml for IL-2 and IL-4 and 0.1 mg/ml for IFN-γ. In addition, BMD (0.01 mg/ml) increased the production of tumor necrosis factor (TNF)-α and IL-12 in mouse peritoneal macrophages (by 2.7-fold for TNF-α and 42.5-fold for IL-12, p<0.05). In conclusion, these data indicate that BMD may have an immune-enhancing effect through the production of various cytokines.

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