Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents
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- Matsuda Hideaki
- School of Pharmaceutical Sciences, Kinki University
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- Hirata Noriko
- School of Pharmaceutical Sciences, Kinki University
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- Kawaguchi Yoshiko
- School of Pharmaceutical Sciences, Kinki University
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- Yamazaki Miho
- School of Pharmaceutical Sciences, Kinki University
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- Naruto Shunsuke
- School of Pharmaceutical Sciences, Kinki University
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- Shibano Makio
- Osaka University of Pharmaceutical Sciences
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- Taniguchi Masahiko
- Osaka University of Pharmaceutical Sciences
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- Baba Kimiye
- Osaka University of Pharmaceutical Sciences
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- Kubo Michinori
- School of Pharmaceutical Sciences, Kinki University
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Melanogenesis stimulation activities of seven ethanolic extracts obtained from Umbelliferae plants used as Chinese crude drugs, namely the roots of Angelica dahurica BENTH. et HOOK., A. biserrata SHEN et YUAN, Notopterygium incisum TING, Heracleum lanatum MICHX., and H. candicans WALL., and the fruits of Cinidium monnieri (L.) CUSSON and C. formosanum YABE, were examined by using cultured murine B16 melanoma cells. Among them, the extract (5, 25 μg/ml) of H. lanatum showed a potent stimulatory effect on melanogenesis with significant enhancement of cell proliferation in a dose-dependent manner. The melanogenesis stimulatory effects of sixteen coumarins (1—16) isolated from the seven Umbelliferae crude drugs were also examined. Among them, linear-furocoumarins [psoralen (1), xanthotoxin (2), bergapten (3), and isopimpinellin (4)] and angular-furocoumarin [sphondin (13)] exhibited potent melanogenesis stimulation activity. From the view point of structure–activity relationships, it may be assumed that a linear-furocoumarin ring having a hydrogen and/or methoxyl group at 5 and 8 positions such as 1, 2, 3 and 4 was preferable for the melanogenesis stimulation activity. The introduction of a prenyl group into the furocoumarin ring was disadvantageous. Coumarin derivatives having a simple coumarin ring were inactive.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (7), 1229-1233, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679604936064
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- NII論文ID
- 10016665359
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7343515
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- PubMed
- 15997104
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可