Antiproliferative Activity of Vietnamese Medicinal Plants.
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- Ueda Jun-ya
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Tezuka Yasuhiro
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Banskota Arjun Hari
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Tran Quan Le
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Tran Qui Kim
- National University-Hochiminh City
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- Harimaya Yuko
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Saiki Ikuo
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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- Kadota Shigetoshi
- Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Abstract
Methanol, methanol–water (1 : 1) and water extracts were prepared from seventy-seven Vietnamese medicinal plants and tested for their antiproliferative activities against human HT-1080 fibrosarcoma cells. Among them, fifteen extracts including seven methanol extracts of Caesalpinia sappan, Catharanthus roseus, Coscinium fenestratum, Eurycoma longifolia, Hydnophytum formicarum and Streptocaulon juventas (collected at two areas), six methanol–water (1 : 1) extracts of Cae. sappan, Cat. roseus, Co. fenestratum, H. formicarum and S. juventas (at two areas), and two water extracts of Cae. sappan and S. juventas exhibited antiproliferative activities in a concentration-dependent manner. Their antiproliferative activities against human cervix HeLa adenocarcinoma, human lung A549 adenocarcinoma, murine colon 26-L5 carcinoma, murine Lewis lung carcinoma (LLC) and murine B16-BL6 melanoma cells were then examined. Co. fenestratum showed selective activity against lung carcinoma and/or lung metastatic cell lines, A549, LLC and B16-BL6, while H. formicarum and S. juventas showed selective activity against human tumor cell lines, HeLa and A549. Characteristic morphological change and DNA fragmentation indicated the antiproliferative activity to be due to the induction of apoptosis.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 25 (6), 753-760, 2002
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679604999168
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- NII Article ID
- 110003638752
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD38XkvV2gsrs%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6175038
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- PubMed
- 12081142
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed