Inhibitory Effect of Propolis on the Growth of Human Leukemia U937

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  • Aso Keiko
    Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical University
  • Kanno Syu-ichi
    Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical University
  • Tadano Takeshi
    Department of Pharmacology, Tohoku Pharmaceutical University
  • Satoh Susumu
    Department of Educational Center, Tohoku Pharmaceutical University
  • Ishikawa Masaaki
    Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku Pharmaceutical University

書誌事項

公開日
2004
資源種別
journal article
DOI
  • 10.1248/bpb.27.727
公開者
公益社団法人 日本薬学会

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説明

We have investigated the effect of propolis (CB Propolis) on the growth of human histiolytic lymphoma U937 cells. We found that propolis strongly inhibited the growth of the cells and macromolecular synthesis in a dose- and time-dependent manner by apoptosis. Propolis at 0.015—0.5 μl/ml showed antitumor activity with an IC50 of 0.18 μl/ml for 3 d. It also inhibits DNA, RNA and protein synthesis with an IC50 of 0.08, 0.17 and 4.3 μl/ml, respectively. The inhibitory effect on DNA synthesis was partially irreversible. Moreover, an apoptotic DNA ladder and chromatin condensation were observed in the same concentration range in which cell growth was inhibited. The caspase inhibitor, Z-Asp-CH2-DCB, prevented DNA fragmentation. These results suggest that the antitumor activity of propolis occurs through the induction of apoptosis. Propolis may be useful as a cancer chemopreventive and chemotherapeutic agent.

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