Antiproliferative Constituents in Plants. 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship.
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- Nagao Tsuneatsu
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Abe Fumiko
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Kinjo Junei
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Okabe Hikaru
- Faculty of Pharmaceutical Sciences, Fukuoka University
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Abstract
The flavonoid fraction from the leaves of Lantana montevidensis BRIQ. (Verbenaceae) showed antiproliferative activity against human gastric adenocarcinoma (MK-1, GI50: 12 μg/ml), human uterus carcinoma (HeLa, 5 μg/ml), and murine melanoma (B16F10, 5 μg/ml) cells in vitro. Bioactivity-guided chemical investigation of the fraction has resulted in the isolation of apigenin (10) and ten 5,6,7-oxygenated flavones: cirsilineol (1), eupatorin (2), 5,4′-dihydroxy-6,7,3′,5′-tetramethoxyflavone (3), 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (4), 5,6,4′-trihydroxy-7,3′,5′-trimethoxyflavone (5), 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (6), 5,3′,4′-trihydroxy-6,7,5′-trimethoxyflavone (7), cirsiliol (8), hispidulin (9), and eupafolin (11). Antiproliferative activity of the isolated flavones, some other related flavones (luteolin, baicalein, 6-hydroxyluteolin, pectolinarigenin, jaceosidin, desmethoxycentaureidin, eupatilin, and chrysin) from other plant materials, and synthetic 6- and 7-methoxyflavones was evaluated, and the structure–activity relationships were examined.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 25 (7), 875-879, 2002
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679605143296
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- NII Article ID
- 110003638777
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD38XlvVChs7s%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6264648
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- PubMed
- 12132661
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed