Effect of Infectious Diseases on the Pathogenesis of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
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- Okamoto-Uchida Yoshimi
- Division of Medicinal Safety Science, National Institute of Health Sciences
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- Nakamura Ryosuke
- Division of Medicinal Safety Science, National Institute of Health Sciences
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- Sai Kimie
- Division of Medicinal Safety Science, National Institute of Health Sciences
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- Imatoh Takuya
- Division of Medicinal Safety Science, National Institute of Health Sciences
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- Matsunaga Kayoko
- Department of Integrative Medical Science for Allergic Disease, School of Medicine, Fujita Health University
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- Aihara Michiko
- Department of Environmental Immuno-Dermatology, Graduate School of Medicine, Yokohama City University
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- Saito Yoshiro
- Division of Medicinal Safety Science, National Institute of Health Sciences
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Abstract
<p>Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, non-genetic factors contributing to the etiology of SJS/TEN are largely unknown. This study aimed to assess the involvement of concurrent infection on the pathological states of SJS/TEN, examining the severity of cutaneous symptoms and ocular involvement as well as the time to onset in drug-induced SJS/TEN patients. We recruited 257 Japanese SJS/TEN patients from June 2006 to September 2013 through a nationwide case collection network and participating hospitals and reviewed the clinical information including patient backgrounds, primary disease and medication status. Association between infection and pathological states of SJS/TEN was assessed using univariate and multivariate analyses. The concurrent infectious group of SJS/TEN patients showed a significantly higher rate of exhibiting severer dermatological and ophthalmological phenotypes and an earlier onset of SJS/TEN than the non-infectious group. Our results suggest that the infection could be a risk factor to cause severer symptoms and earlier onset of SJS/TEN.</p>
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 40 (9), 1576-1580, 2017
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679607883776
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- NII Article ID
- 130006038757
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 028470780
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- PubMed
- 28867742
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed