A Meta-analysis of the Association of <i>PPAR</i>γ rs1801282 Polymorphism and NSAID Usage with the Risk of Developing Cancer
-
- Nagao Mai
- Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School
-
- Sato Youichi
- Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School
-
- Yamauchi Aiko
- Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School
Bibliographic Information
- Other Title
-
- A Meta-analysis of the Association of PPARγ rs1801282 Polymorphism and NSAID Usage with the Risk of Developing Cancer
Search this article
Description
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) is correlated with a reduced risk of cancer through the reduction of inflammation, which is an important risk factor. Several studies have investigated polymorphisms in the peroxisome proliferator-activated receptor gamma (PPARγ) gene and NSAID use in association with cancer risk. However, these studies yielded mixed results. Therefore, we performed a meta-analysis to evaluate the association of PPARγ polymorphisms and NSAID usage with cancer risk. We conducted a comprehensive search of PubMed through May 2013. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated using the fixed-effect or random-effect model. A comprehensive search of the database revealed 6 studies that fulfilled the inclusion criteria. NSAID use was significantly associated with decreased cancer risk regardless of PPARγ rs1801282 genotypes. In a stratified analysis by cancer type, NSAID users who were minor allele carriers had significantly decreased colon cancer risk compared to non-NSAID users (OR=0.73, 95% CI=0.57–0.93), whereas NSAID users homozygous for the major allele had significantly decreased risk for cancers other than colon cancer compared to non-NSAID users (OR=0.79, 95% CI=0.69–0.91). Our results suggest that the association of PPARγ rs1801282 polymorphism and NSAID use with the risk of cancer may differ according to cancer type.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 37 (6), 1062-1067, 2014
The Pharmaceutical Society of Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679607989632
-
- NII Article ID
- 130004147354
-
- NII Book ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC2cjot1GgtA%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL BIB ID
- 025479009
-
- PubMed
- 24882418
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
- OpenAIRE
-
- Abstract License Flag
- Disallowed