Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
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- Nakamura Seikou
- Kyoto Pharmaceutical University
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
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Abstract
Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed leaves of Hydrangea macrophylla var. thunbergii, piperlonguminine and retrofractamide A from the fruit of Piper chaba, and tetramethylkaempferol and pentamethylquercetin from the rhizomes of Kaempferia parviflora, are reviewed.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 37 (6), 884-891, 2014
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679607997184
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- NII Article ID
- 130004147348
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2cjot1Giug%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 025478777
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- PubMed
- 24882400
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed