Effects of Ashwagandha (Roots of <i>Withania somnifera</i>) on Neurodegenerative Diseases

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  • Kuboyama Tomoharu
    Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama
  • Tohda Chihiro
    Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama
  • Komatsu Katsuko
    Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama

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  • Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases

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Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer’s disease and spinal cord injury.

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