Impact of CYP2C9 Polymorphism Found in the Chinese Population on the Metabolism of Propofol in Vitro
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- Lian Qing-Quan
- Department of Anesthesiology, The Second Affiliated Hospital of Wenzhou Medical University
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- Pan Pei-Pei
- School of Pharmacy, Wenzhou Medical University
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- Li Jun-Wei
- School of Pharmacy, Wenzhou Medical University
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- Lin Han
- Department of Anesthesiology, The Second Affiliated Hospital of Wenzhou Medical University
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- Hu Guo-Xin
- School of Pharmacy, Wenzhou Medical University
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- Zuo Ming-Zhang
- Department of Anesthesia, Beijing Hospital, Ministry of Health
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- Cai Jian-Ping
- The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health
書誌事項
- タイトル別名
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- Impact of CYP2C9 Polymorphism Found in the Chinese Population on the Metabolism of Propofol <i>in Vitro</i>
この論文をさがす
抄録
The microsomal CYP2C9 alleles involved in the biotransformation of propofol, a widely used anesthetic agent, were investigated in vitro. To examine the enzymatic activity of the CYP2C9 alleles, kinetic parameters for propofol 4-hydroxylation were determined in recombinant human P450s CYP2C9 microsomes from Sf21 insects cells carrying CYP2C9*1 and other variants. Some of the variants showed decreased enzyme activity compared with the wild type, as previously reported. Two variants (CYP2C9*36 and *56) were found substantially to increase intrinsic clearance relative to the wild type variant. Most variants significantly (p<0.05) decreased intrinsic clearance of propofol compared with the wild type, except *11, *47, and *54. This study is the first to report these rare alleles for propofol metabolism, providing fundamental data for further clinical studies on CYP2C9 alleles for propofol metabolism in vivo.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 38 (4), 531-535, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679608485120
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- NII論文ID
- 130005062262
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 026283535
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- PubMed
- 25832633
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可