Lactobacillus acidophilus Strain L-92 Induces CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells and Suppresses Allergic Contact Dermatitis

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  • Shah Mohammad Monir
    Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University Laboratory of Pharmacology, Department of Bioactive molecules, Gifu Pharmaceutical University Department of Microbiology, Graduate School of Medicine, Gifu University
  • Saio Masanao
    Department of Immunopathology, Graduate School of Medicine, Gifu University
  • Yamashita Hirotaka
    Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University Laboratory of Pharmacology, Department of Bioactive molecules, Gifu Pharmaceutical University
  • Tanaka Hiroyuki
    Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University Laboratory of Pharmacology, Department of Bioactive molecules, Gifu Pharmaceutical University
  • Takami Tsuyoshi
    Department of Immunopathology, Graduate School of Medicine, Gifu University
  • Ezaki Takayuki
    Department of Microbiology, Graduate School of Medicine, Gifu University
  • Inagaki Naoki
    Laboratory of Bioresponses and Regulation, United Graduate School of Drug Discovery and Medical Information Science, Gifu University Laboratory of Pharmacology, Department of Bioactive molecules, Gifu Pharmaceutical University

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タイトル別名
  • <i>Lactobacillus acidophilus</i> Strain L-92 Induces CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> Regulatory T Cells and Suppresses Allergic Contact Dermatitis

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The anti-allergic mechanism of heat-killed Lactobacillus acidophilus strain L-92 has not been fully investigated. Recent studies have reported that CD4+CD25+Foxp3+ (forkhead box P3) T regulatory (Treg) cells play important roles in controlling allergic diseases. Hence, we examined the effect of orally administered L-92 on CD4+CD25+Foxp3+ cell populations. BALB/c mice were supplemented daily with L-92 by gavage for 5 weeks. 2,4-Dinitrofluorobenzene (DNFB) was used to induce allergic contact dermatitis (ACD) in mice. Fluorescent-activated cell sorter (FACS) analysis was used to determine CD4+CD25+Foxp3+ T cell populations in spleen and cervical lymph nodes (CLN). Interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and Foxp3 mRNA expressions in mouse ear skin were investigated by real-time reverse transcription-polymerase chain reaction (RT-PCR). The percentage of CD4+CD25+Foxp3+ T cell populations were significantly increased in both spleen and CLN of L-92-fed group than vehicle and control. In addition, L-92 produced higher levels of Foxp3, IL-10 and TGF-β compared to control mice. These results suggest that L-92 can up-regulate the number of Treg cells to suppress the progression of DNFB-induced contact dermatitis in mice.

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